Protopsaltis John, Kokkoris Stelios, Nikolopoulos George, Spyropoulou Panagiota, Katsaros Thomas, Salvanos Leonardos, Brestas Paris, Korantzopoulos Panagiotis, Melidonis Andreas
Diabetes Center, 'Tzanio' General Hospital, Piraeus, Greece.
Med Princ Pract. 2007;16(3):222-5. doi: 10.1159/000100394.
The aim of this study was to elucidate if apoptosis dysregulation is present in type 1 diabetic patients with microalbuminuria.
The following variables were determined in 29 type 1 diabetic patients: the duration of diabetes, soluble Fas (sFas), Bcl-2, hemoglobin A(1c) levels, glomerular filtration rate (GFR) and microalbuminuria, using the urine albumin to urine creatinine ratio (ACR). Age and gender were assessed and patients were categorized into two groups, according to their ACR: the microalbuminuric (MA) group with an ACR > or =30 mg/g, and the normoalbuminuric (NA) group with an ACR <30 mg/g.
The differences between the two groups regarding sFas, Bcl-2 and GFR were not statistically significant. However, in the MA group, a significant positive relationship between sFas and ACR was observed (r = 0.736, p = 0.015). Dividing patients into two subgroups--mild versus severe (ACR > or =150 mg/g) microalbuminuric patients--significant differences in sFas (60.4 vs. 87.2 pg/ml; p = 0.047) and GFR (113 vs. 69.5 ml min(-1) 1.73 m(-2); p = 0.021) were observed, whereas in Bcl-2, the difference was not significant (77.96 vs. 71.13 ng/ml).
At the early stages of diabetic nephropathy in type 1 diabetic patients, there seems to be a dysregulation of apoptosis, as expressed by enhanced sFas levels, leading to the speculation that the prevalence of antiapoptotic mechanisms (sFas) may promote mesangial proliferation.
本研究旨在阐明1型糖尿病合并微量白蛋白尿患者是否存在凋亡失调。
测定了29例1型糖尿病患者的以下变量：糖尿病病程、可溶性Fas（sFas）、Bcl-2、糖化血红蛋白A1c水平、肾小球滤过率（GFR）以及微量白蛋白尿，采用尿白蛋白与尿肌酐比值（ACR）进行评估。评估了患者的年龄和性别，并根据ACR将患者分为两组：ACR≥30mg/g的微量白蛋白尿（MA）组和ACR<30mg/g的正常白蛋白尿（NA）组。
两组在sFas、Bcl-2和GFR方面的差异无统计学意义。然而，在MA组中，观察到sFas与ACR之间存在显著正相关（r = 0.736，p = 0.015）。将患者分为两个亚组——轻度与重度（ACR≥150mg/g）微量白蛋白尿患者——观察到sFas（60.4对87.2pg/ml；p = 0.047）和GFR（113对69.5ml·min⁻¹·1.73m⁻²；p = 0.021）存在显著差异，而Bcl-2的差异不显著（77.9
