Yokota Hajime, Guo Jianfei, Matoba Munetaka, Higashi Kotaro, Tonami Hisao, Nagao Yosinobu
Department of Radiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan.
J Magn Reson Imaging. 2007 May;25(5):992-9. doi: 10.1002/jmri.20902.
To determine the biochemical characteristics of lung cancer tissue using in vitro (1)H-MRS, and investigate the correlation between survival probabilities and lactate (Lac), creatine (Cr), and choline (Cho) concentrations measured by in vitro (1)H-MRS.
A total of 21 patients with lung cancer were included in this retrospective study. (1)H-MRS spectra measurements were performed at 6.35T using a JNM-EX270, high-resolution FT-NMR spectrometer.
When normal lung tissue was compared with lung cancer tissue, significant differences were noted most consistently in the levels of Lac and Cho, with lung cancer tissue showing higher values than normal lung tissue. Lac concentrations of lung cancer tissue were significantly higher in patients with recurrence compared to patients without recurrence (0.285 +/- 0.096 mumol/g). The mean overall survival of patients in the low-Lac group was 50.28 +/- 6.47 months, which is significantly higher compared to the high-Lac group, which had a mean survival time of only 30.49 +/- 5.41 months.
Kaplan-Meier analysis of the data showed that the overall and disease-free survival probabilities were significantly higher in patients with low tumor Lac values than in those with high tumor Lac concentrations.
使用体外氢质子磁共振波谱（1H-MRS）测定肺癌组织的生化特征，并研究通过体外1H-MRS测量的乳酸（Lac）、肌酸（Cr）和胆碱（Cho）浓度与生存概率之间的相关性。
本回顾性研究共纳入21例肺癌患者。使用JNM-EX270高分辨率傅里叶变换核磁共振光谱仪在6.35T磁场下进行1H-MRS光谱测量。
将正常肺组织与肺癌组织进行比较时，Lac和Cho水平的差异最为显著，肺癌组织的值高于正常肺组织。与未复发患者相比，复发患者的肺癌组织Lac浓度显著更高（0.285±0.096μmol/g）。低Lac组患者的平均总生存期为50.28±6.47个月，与高Lac组相比显著更高，高Lac组的平均生存时间仅为30.49±5.41个月。
对数据进行的Kaplan-Meier分析表明，肿瘤Lac值低的患者的总生存期和无病生存期概率显著高于肿瘤Lac浓度高的患者。
