Charles C H, Abler A S, Lau L F
Department of Genetics, University of Illinois College of Medicine, Chicago 60612.
Oncogene. 1992 Jan;7(1):187-90.
We report the cDNA sequence of 3CH134, an immediate early gene whose transcription is rapidly and transiently stimulated by serum growth factors. 3CH134 encodes a 367 amino acid protein that does not share significant sequence similarity with any known protein. 3CH134 is inducible through multiple signal transduction pathways, and in the adult mouse is expressed predominantly in the lung. Using affinity-purified antibodies, we have identified the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short half-life.
我们报告了3CH134的cDNA序列，它是一个立即早期基因，其转录受到血清生长因子的快速短暂刺激。3CH134编码一种367个氨基酸的蛋白质，该蛋白质与任何已知蛋白质都没有显著的序列相似性。3CH134可通过多种信号转导途径诱导表达，在成年小鼠中主要在肺中表达。我们使用亲和纯化抗体在血清刺激的Balb/c 3T3细胞中鉴定出了3CH134蛋白，并确定其半衰期较短。
