• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Attenuated aerobic exercise capacity in CD36 deficiency.CD36缺乏时有氧运动能力减弱。
J Med Genet. 2007 Jul;44(7):445-7. doi: 10.1136/jmg.2007.050070. Epub 2007 Apr 5.
2
Metabolic changes in human CD36 deficiency displayed by glucose loading.葡萄糖负荷显示的人类CD36缺乏症中的代谢变化。
Thromb Haemost. 2001 Oct;86(4):995-9.
3
CD36, but not GPR120, is required for efficient fatty acid utilization during endurance exercise.在耐力运动期间高效利用脂肪酸需要CD36，而不是GPR120。
Biosci Biotechnol Biochem. 2014;78(11):1871-8. doi: 10.1080/09168451.2014.940835. Epub 2014 Jul 29.
4
Regulation of fatty acid transport by fatty acid translocase/CD36.脂肪酸转位酶/CD36对脂肪酸转运的调控
Proc Nutr Soc. 2004 May;63(2):245-9. doi: 10.1079/PNS2004331.
5
CD36-dependent fatty acid uptake regulates expression of peroxisome proliferator activated receptors.CD36 依赖性脂肪酸摄取调节过氧化物酶体增殖物激活受体的表达。
Biochem Soc Trans. 2005 Feb;33(Pt 1):311-5. doi: 10.1042/BST0330311.
6
A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism.骨骼肌中FAT/CD36的无效突变揭示了其在胰岛素和AICAR刺激的脂肪酸代谢中的重要作用。
Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1740-9. doi: 10.1152/ajpendo.00579.2006. Epub 2007 Jan 30.
7
Regulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exercise.运动期间人体骨骼肌中血浆长链脂肪酸氧化与摄取的关系调控
Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E696-705. doi: 10.1152/ajpendo.00001.2004. Epub 2004 Jun 8.
8
Pulmonary gas exchange and exercise capacity in patients with systemic lupus erythematosus.系统性红斑狼疮患者的肺气体交换与运动能力
J Rheumatol. 1999 Dec;26(12):2591-4.
9
Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia.脂肪酸转位酶/CD36缺乏在缺血前后均不会在能量或功能上损害心脏。
Circulation. 2004 Mar 30;109(12):1550-7. doi: 10.1161/01.CIR.0000121730.41801.12. Epub 2004 Mar 15.
10
CD36 deficiency predisposing young children to fasting hypoglycemia.CD36 缺乏使幼儿易发生空腹低血糖症。
Metabolism. 2011 Jun;60(6):881-7. doi: 10.1016/j.metabol.2010.08.008. Epub 2010 Oct 13.

引用本文的文献

1
Exploring the Association Between rs1761667 Polymorphism and Susceptibility to Non-Contact Tissue Injuries in Moroccan Elite Cyclists and Field Hockey Players: A Pilot Study.探索rs1761667多态性与摩洛哥精英自行车运动员和曲棍球运动员非接触性组织损伤易感性之间的关联：一项初步研究。
Genes (Basel). 2025 May 28;16(6):651. doi: 10.3390/genes16060651.
2
Genotypic and Allelic Distribution of the rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study.摩洛哥高水平运动员中rs1761667多态性的基因型和等位基因分布：一项初步研究。
Genes (Basel). 2024 Mar 27;15(4):419. doi: 10.3390/genes15040419.
3
Association between "cluster of differentiation 36 (CD36)" and adipose tissue lipolysis during exercise training: a systematic review.运动训练期间“分化簇36（CD36）”与脂肪组织脂解之间的关联：一项系统综述
Front Physiol. 2023 Nov 22;14:1256440. doi: 10.3389/fphys.2023.1256440. eCollection 2023.
4
FAT/CD36 Participation in Human Skeletal Muscle Lipid Metabolism: A Systematic Review.FAT/CD36在人类骨骼肌脂质代谢中的作用：一项系统评价。
J Clin Med. 2022 Dec 31;12(1):318. doi: 10.3390/jcm12010318.
5
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.肌内脂质的细胞内定位不同，以及 PKCε/ PKCθ 活性降低可维持运动训练小鼠的肌肉胰岛素敏感性。
Diabetologia. 2023 Mar;66(3):567-578. doi: 10.1007/s00125-022-05838-8. Epub 2022 Dec 1.
6
The Regulation of Fat Metabolism During Aerobic Exercise.有氧运动过程中的脂肪代谢调节。
Biomolecules. 2020 Dec 21;10(12):1699. doi: 10.3390/biom10121699.
7
CD36 is essential for endurance improvement, changes in whole-body metabolism, and efficient PPAR-related transcriptional responses in the muscle with exercise training.CD36对于耐力提升、全身代谢变化以及运动训练后肌肉中与PPAR相关的有效转录反应至关重要。
Physiol Rep. 2017 May;5(10):e13282. doi: 10.14814/phy2.13282.
8
Associations between CD36 gene polymorphisms, fat tolerance and oral fat preference in a young-adult population.年轻成年人群中CD36基因多态性、脂肪耐受性与口腔脂肪偏好之间的关联。
Eur J Clin Nutr. 2016 Nov;70(11):1325-1331. doi: 10.1038/ejcn.2016.132. Epub 2016 Jul 27.
9
Globular warming: how fat gets to the furnace.
Nat Med. 2011 Feb;17(2):157-9. doi: 10.1038/nm0211-157.
10
Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes.在撒哈拉以南非洲地区，CD36基因一个无义变异体存在正向选择，但与严重疟疾表型无关联。
Hum Mol Genet. 2009 Jul 15;18(14):2683-92. doi: 10.1093/hmg/ddp192. Epub 2009 Apr 29.

本文引用的文献

1
Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training.耐力运动训练后，骨骼肌中FAT/CD36与肉碱棕榈酰转移酶I的共免疫沉淀与脂肪氧化成比例增加。
Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E254-60. doi: 10.1152/ajpendo.00051.2006. Epub 2006 May 2.
2
Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation.人骨骼肌线粒体膜上脂肪酸转运蛋白的鉴定：在脂肪酸氧化中的重要作用。
Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E509-15. doi: 10.1152/ajpendo.00312.2005. Epub 2005 Oct 11.
3
Regulation of fatty acid transport by fatty acid translocase/CD36.脂肪酸转位酶/CD36对脂肪酸转运的调控
Proc Nutr Soc. 2004 May;63(2):245-9. doi: 10.1079/PNS2004331.
4
Metabolic changes in human CD36 deficiency displayed by glucose loading.葡萄糖负荷显示的人类CD36缺乏症中的代谢变化。
Thromb Haemost. 2001 Oct;86(4):995-9.
5
Phenotype-genotype correlation in CD36 deficiency types I and II.I型和II型CD36缺乏症的表型-基因型相关性
Thromb Haemost. 2000 Sep;84(3):436-41.
6
Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice.CD36基因敲除小鼠肌肉和脂肪组织中长链脂肪酸摄取及利用存在缺陷。
J Biol Chem. 2000 Oct 20;275(42):32523-9. doi: 10.1074/jbc.M003826200.
7
Plasma catecholamine and blood lactate responses to incremental arm and leg exercise.血浆儿茶酚胺和血乳酸对递增式手臂和腿部运动的反应。
Med Sci Sports Exerc. 2000 Mar;32(3):608-13. doi: 10.1097/00005768-200003000-00009.
8
Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin.FAT/CD36在肌肉中的特异性过表达通过收缩肌肉增强脂肪酸氧化，降低血浆甘油三酯和脂肪酸水平，并提高血浆葡萄糖和胰岛素水平。
J Biol Chem. 1999 Sep 17;274(38):26761-6. doi: 10.1074/jbc.274.38.26761.
9
Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle.激素敏感性脂肪酶在骨骼肌中的表达及其受肾上腺素的调节
Biochem J. 1999 Jun 1;340 ( Pt 2)(Pt 2):459-65.
10
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.鉴定Cd36（脂肪）为导致高血压大鼠脂肪酸和葡萄糖代谢缺陷的胰岛素抵抗基因。
Nat Genet. 1999 Jan;21(1):76-83. doi: 10.1038/5013.

CD36缺乏时有氧运动能力减弱。

Attenuated aerobic exercise capacity in CD36 deficiency.

作者信息

Yanai Hidekatsu, Watanabe Ichiro, Ishii Kojiro, Morimoto Mie, Fujiwara Hironobu, Yoshida Shigeru, Hui Shu-Ping, Matsuno Kazuhiko, Chiba Hitoshi

机构信息

Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo 060-8648, Japan.

出版信息

J Med Genet. 2007 Jul;44(7):445-7. doi: 10.1136/jmg.2007.050070. Epub 2007 Apr 5.

DOI:10.1136/jmg.2007.050070
PMID:17412877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2598008/
Abstract

BACKGROUND

An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency.

METHODS

We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer.

RESULTS

In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate.

CONCLUSION

This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.

摘要

背景

在CD36基因敲除或CD36过表达的小鼠中，已证实CD36在肌肉脂肪酸（FA）摄取中起重要作用。在低于无氧阈值（AT）的轻度运动期间，FA是能量产生的主要底物。我们研究了人类的有氧运动能力是否会受到CD36缺乏的影响。

方法

我们调查了正常参与者（n = 22）和CD36缺乏参与者（n = 12）在蹬踩自行车测力计过程中的通气阈值（VT）和血清FA变化。

结果

在CD36缺乏的参与者中，峰值工作率时FA水平未降低，而正常参与者的FA水平下降了约50%。CD36缺乏的参与者的VT显著低于正常参与者。在峰值工作率时，观察到VT与FA百分比变化之间存在显著相关性。

结论

本研究发现CD36缺乏时FA利用减少且有氧运动能力减弱，表明CD36介导的FA氧化是人类有氧运动能力的重要决定因素。