Tadagaki Kenjiro, Yamanishi Koichi, Mori Yasuko
Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.
J Gen Virol. 2007 May;88(Pt 5):1423-1428. doi: 10.1099/vir.0.82665-0.
Human herpesvirus 7 (HHV-7) is a member of the subfamily Betaherpesvirinae that exhibits a restricted cell tropism, preferentially infecting CD4+ T cells in vitro. HHV-7 encodes two functional chemokine receptors, U12 and U51. The human chemokines that act as ligands for these receptors have been identified as CCL22 (the natural ligand for CCR4) and CCL19 (the natural ligand for CCR7). It was found that murine L1.2 cells co-expressing CCR4 or CCR7 and U12 responded to both CCL22 and CCL19 in calcium-mobilization assays, but migrated in response only to the appropriate ligand for the expressed cellular receptor. Similar results were obtained with L1.2 cells co-expressing CCR4 or CCR7 with U51. These results suggest that the HHV-7 U12 and U51 receptors can function in concert with CCR4 and CCR7 in host-cell signalling pathways.
人类疱疹病毒7型（HHV - 7）是β疱疹病毒亚科的成员，其细胞嗜性有限，在体外优先感染CD4 + T细胞。HHV - 7编码两种功能性趋化因子受体，U12和U51。已确定作为这些受体配体的人类趋化因子为CCL22（CCR4的天然配体）和CCL19（CCR7的天然配体）。研究发现，共表达CCR4或CCR7与U12的小鼠L1.2细胞在钙动员试验中对CCL22和CCL19均有反应，但仅对表达的细胞受体的相应配体发生迁移反应。共表达CCR4或CCR7与U51的L1.2细胞也得到了类似结果。这些结果表明，HHV - 7的U12和U51受体可在宿主细胞信号通路中与CCR4和CCR7协同发挥作用。
