Pontejo Sergio M, Murphy Philip M
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Leukoc Biol. 2017 Nov;102(5):1199-1217. doi: 10.1189/jlb.4RU0417-145RR. Epub 2017 Aug 28.
Viruses use diverse strategies to elude the immune system, including copying and repurposing host cytokine and cytokine receptor genes. For herpesviruses, the chemokine system of chemotactic cytokines and receptors is a common source of copied genes. Here, we review the current state of knowledge about herpesvirus-encoded chemokines and discuss their possible roles in viral pathogenesis, as well as their clinical potential as novel anti-inflammatory agents or targets for new antiviral strategies.
病毒采用多种策略来逃避免疫系统，包括复制和重新利用宿主细胞因子及细胞因子受体基因。对于疱疹病毒而言，趋化性细胞因子和受体的趋化因子系统是复制基因的常见来源。在此，我们综述了关于疱疹病毒编码趋化因子的当前知识状况，并讨论它们在病毒发病机制中的可能作用，以及它们作为新型抗炎剂或新抗病毒策略靶点的临床潜力。
