一种合成肽对慢性肾性高血压中血管紧张素转换酶的抑制作用。

The inhibition of angiotensin converting enzyme in chronic renal hypertension by a synthetic peptide.

作者信息

Loyke H F

出版信息

Proc Soc Exp Biol Med. 1975 Nov;150(2):457-60. doi: 10.3181/00379727-150-39055.

Abstract

Renal hypertension was produced in 14 Sprague-Dawley rats by ligating both poles of one kidney followed in one week by unilateral nephrectomy. Biweekly subcutaneous injections of SQ 20858 reduced the blood pressure in the chronic renal hypertensive animals. Upon discontinuing the injections the blood pressure rose to pretreatment levels. No angiotensin II activity was seen in seven of the renal group treated with SQ indicating a complete block in serum converting enzyme activity. Likewise, serum with only angiotensin I activity when added to normal serum containing converting enzyme, continued to show angiotensin I activity. It is concluded that SQ 20858 is effective in lowering blood pressure in chronic renal hypertensive rats presumably by partially inhibiting converting enzyme.

摘要

通过结扎14只斯普拉格-道利大鼠一侧肾脏的两极，一周后进行单侧肾切除术，制造出肾性高血压模型。对慢性肾性高血压动物每两周进行一次皮下注射SQ 20858，可降低其血压。停止注射后，血压回升至治疗前水平。在用SQ治疗的肾性高血压组中，有7只未检测到血管紧张素II活性，表明血清转化酶活性被完全阻断。同样，仅含血管紧张素I活性的血清加入含有转化酶的正常血清中后，仍显示血管紧张素I活性。由此得出结论，SQ 20858可能通过部分抑制转化酶，有效降低慢性肾性高血压大鼠的血压。