实验性高血压中肾素-血管紧张素系统抑制剂，以及关于在输注转化酶抑制剂期间测量血管紧张素I、II和III的说明
Inhibitors of the renin-angiotensin system in experimental hypertension, with a note on the measurement of angiotensin I, II and III during infusion of converting-enzyme inhibitor.
作者信息
Morton J J, Casals-Stenzel J, Lever A F, Millar J A, Riegger A J, Tree M
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 2(Suppl 2):233S-241S. doi: 10.1111/j.1365-2125.1979.tb04695.x.
Abstract
1 Prolonged infusion (11 h) of both saralasin and angiotensin-converting enzyme inhibitor (SQ20881) gradually lowered BP in two-kidney hypertensive rats to levels similar to that in normotensive rats infused with dextrose. 2 Saralasin did not lower BP in DOCA-salt hypertensive rats. 3 These observations support the notion that in chronic renal hypertension, angiotensin II may maintain hypertension by a slowly developing action. 4 Plasma angiotensin II in rats infused with SQ20881 was suppressed relative to renin, but was not eliminated. 5 Chromatography of angiotensin II extracts from dogs infused with converting enzyme inhibitor (SQ14,225) showed that the very high levels of angiotensin I achieved after treatment with SQ14,225 can lead to falsely high estimated angiotensin II levels as a result of angiotensin I cross-reacting with the angiotensin II assay.
摘要
- 对双肾高血压大鼠长时间输注（11小时）沙拉新和血管紧张素转换酶抑制剂（SQ20881），可使血压逐渐降至与输注葡萄糖的正常血压大鼠相似的水平。2. 沙拉新对去氧皮质酮盐高血压大鼠的血压没有降低作用。3. 这些观察结果支持这样一种观点，即在慢性肾性高血压中，血管紧张素II可能通过缓慢发展的作用来维持高血压。4. 与肾素相比，输注SQ20881的大鼠血浆血管紧张素II受到抑制，但并未消除。5. 对输注转换酶抑制剂（SQ14,225）的犬的血管紧张素II提取物进行色谱分析表明，用SQ14,225治疗后达到的非常高的血管紧张素I水平，由于血管紧张素I与血管紧张素II测定法发生交叉反应，可能导致血管紧张素II水平的估计值出现假性升高。
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