Sanal Ozden, Turkkani Gulten, Gumruk Fatma, Yel Leman, Secmeer Gulten, Tezcan Ilhan, Kara Ates, Ersoy Fugen
Divisions of Immunology, Hacettepe University Children's Hospital, Ankara, Turkey.
Pediatr Infect Dis J. 2007 Apr;26(4):366-8. doi: 10.1097/01.inf.0000258696.64507.0f.
Interleukin-12 receptor beta-1 (IL-12Rbeta1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12Rbeta1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.
白细胞介素-12受体β1（IL-12Rβ1）缺陷通常与对弱致病性分枝杆菌和沙门氏菌属的选择性易感性相关。患者很少经历由其他生物体引起的感染。我们报告了一名5岁的IL-12Rβ1缺乏症患者，该患者相隔6个月出现复发性内脏利什曼病。该患者对脂质体两性霉素B治疗反应良好。
