Hong Seung Phil, Ahn Sung Ku
Department of Dermatology and Institute of Basic Medical Science, Yonsei University Wonju College of Medicine, Wonju, Korea.
Am J Dermatopathol. 2007 Apr;29(2):187-9. doi: 10.1097/DAD.0b013e318033275e.
We report a case of sporadic cutaneous neurofibroma showing diffuse eosinophil infiltration in a 72-year-old woman. The neurofibroma had been on the skin of the left anterior shoulder for approximately 10 years. The presence of mast cells is well known in neurofibroma. However, infiltration of neurofibromas by eosinophils has not yet been documented. We propose that eosinophil infiltration is mediated by the effects of mast cells. We suggest that this is indirect evidence that mast cells in some neurofibromas are not quiescent but active. We also reintroduce the notion that acid-fast stains are a useful method to discriminate between mast cell granules and eosinophil granules.
我们报告了一例72岁女性的散发性皮肤神经纤维瘤，其表现为弥漫性嗜酸性粒细胞浸润。该神经纤维瘤位于左前肩部皮肤，已有约10年。肥大细胞在神经纤维瘤中的存在是众所周知的。然而，嗜酸性粒细胞浸润神经纤维瘤的情况尚未见文献记载。我们认为嗜酸性粒细胞浸润是由肥大细胞的作用介导的。我们提出这是间接证据，表明某些神经纤维瘤中的肥大细胞并非静止而是活跃的。我们还重新引入了抗酸染色是区分肥大细胞颗粒和嗜酸性粒细胞颗粒的有用方法这一观点。
