Nagrani Neha S, Bhawan Jag
Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118-2415, USA.
Dermatopathology (Basel). 2022 Dec 26;10(1):1-19. doi: 10.3390/dermatopathology10010001.
The first description of histopathological variants of neurofibroma dates back to 1994. Over the years, many individual case reports elucidating unusual histologic features in neurofibroma have been added to the literature, some of which have defined criteria, with the others falling under the roof of benign neural neoplasms. These unusual features, which sometimes may lead to pauses in identifying a common benign tumor such as neurofibroma. Awareness of these variants may help dermatopathologists avoid misinterpretation. Thus, this review aims to summarize all novel and unusual histopathological variants of cutaneous neurofibroma reported to date, in addition to any unusual variants that we encountered in our practice.
神经纤维瘤组织病理学变异的首次描述可追溯到1994年。多年来，许多阐明神经纤维瘤异常组织学特征的个案报告被纳入文献，其中一些报告定义了标准，其他的则属于良性神经肿瘤范畴。这些异常特征有时可能会在识别神经纤维瘤这种常见良性肿瘤时造成停顿。了解这些变异有助于皮肤病理学家避免误诊。因此，本综述旨在总结迄今报道的皮肤神经纤维瘤所有新的和异常的组织病理学变异，以及我们在实践中遇到的任何异常变异。
