Ho Angela L, O'Malley Martin E, Tomlinson George A
Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
J Comput Assist Tomogr. 2007 Mar-Apr;31(2):165-8. doi: 10.1097/01.rct.0000237816.11054.09.
To evaluate the incidence of adverse events with the universal use of iodixanol for computed tomography (CT) and compare it with periods when iohexol was used exclusively.
Iodixanol was used for CT in 15,142 consecutive patients and compared with 22,044 patients who received iohexol.
Adverse events were observed in 116 patients (0.77%) who received iodixanol and in 54 patients (0.25%) who received iohexol (P < 0.001). Immediate and delayed adverse events were seen in 76 and 40 patients (0.50% and 0.26%, respectively) who received iodixanol and in 52 and 2 patients (0.24% and 0.01%, respectively) who received iohexol, respectively (immediate, P = 0.002; delayed, P < 0.001). Adverse events with iodixanol and iohexol were as follows: mild, 89% and 98%; moderate, 10% and 2%; and severe, 1% and 0%, respectively.
Adverse events occurred in less than 1% of patients receiving either contrast agent. However, the incidence of immediate and delayed adverse events was significantly higher with iodixanol than iohexol.
评估在计算机断层扫描（CT）中普遍使用碘克沙醇时不良事件的发生率，并将其与仅使用碘海醇的时期进行比较。
对15142例连续接受CT检查的患者使用碘克沙醇，并与22044例接受碘海醇的患者进行比较。
接受碘克沙醇的116例患者（0.77%）和接受碘海醇的54例患者（0.25%）出现了不良事件（P<0.001）。接受碘克沙醇的76例和40例患者（分别为0.50%和0.26%）出现了即时和延迟不良事件，接受碘海醇的患者分别为52例和2例（分别为0.24%和0.01%）（即时，P=0.002；延迟，P<0.001）。碘克沙醇和碘海醇的不良事件情况如下：轻度，分别为89%和98%；中度，分别为10%和2%；重度，分别为1%和0%。
接受这两种造影剂的患者中不良事件发生率均低于1%。然而，碘克沙醇导致的即时和延迟不良事件发生率显著高于碘海醇。
