Kavouras Stavros A, Panagiotakos Demosthenes B, Pitsavos Christos, Chrysohoou Christina, Anastasiou Costas A, Lentzas Yannis, Stefanadis Christodoulos
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Med Sci Sports Exerc. 2007 Apr;39(4):606-11. doi: 10.1249/mss.0b013e31803084eb.
We aimed to evaluate the relationship of physical activity and obesity with glycemic control and insulin resistance.
A randomized, population-based, cross-sectional health and nutrition survey was conducted in the province of Athens, Greece. Subjects included 1514 men and 1528 women without evidence of cardiovascular or other chronic disease. Participants were classified as inactive, minimally active, or health-enhancing physical activity (HEPA) active based on the International Physical Activity Questionnaire. Insulin sensitivity was assessed by the homeostatic model (HOMA), and overweight or obesity was assessed according to BMI (BMI >or= 25). Related social, biological, and lifestyle factors were also recorded and used as potential confounders.
Five hundred sixty-five (37.3%) men and 493 (32.3%) women were classified as physically active. From the 1058 (34.8%) subjects who were classified as active, 306 (10.1%) met the criteria for HEPA active, and the rest were minimally active. HEPA active and minimally active subjects smoked less and had lower BMI, waist, and waist-to-hip ratio. Lean and overweight or obese subjects with sedentary lifestyle had greater levels of glucose, insulin, and insulin resistance [corrected] However, overweight or obese volunteers with physical activity levels classified as HEPA had similar levels of glucose and insulin sensitivity, with lower insulin than lean inactive individuals. Linear regression analysis between HOMA and physical activity, taking into consideration several social and biological factors, showed that physical activity (MET x min x wk(-1)), age, BMI, and total energy intake are important predictors of HOMA, whereas other factors such as waist circumference did not reach statistical significance.
Our data show that physical activity is a significant factor on insulin sensitivity, whereas increased physical activity may ameliorate the well-known effects of obesity on insulin sensitivity.
我们旨在评估身体活动及肥胖与血糖控制和胰岛素抵抗之间的关系。
在希腊雅典省开展了一项基于人群的随机横断面健康与营养调查。研究对象包括1514名男性和1528名女性，他们均无心血管疾病或其他慢性病迹象。根据国际身体活动问卷，参与者被分为不活跃、轻度活跃或增进健康身体活动（HEPA）活跃组。通过稳态模型（HOMA）评估胰岛素敏感性，根据体重指数（BMI≥25）评估超重或肥胖情况。还记录了相关的社会、生物学和生活方式因素，并将其用作潜在混杂因素。
565名（37.3%）男性和493名（32.3%）女性被归类为身体活跃。在1058名（34.8%）被归类为活跃的受试者中，306名（10.1%）符合HEPA活跃标准，其余为轻度活跃。HEPA活跃和轻度活跃的受试者吸烟较少，BMI、腰围和腰臀比更低。久坐不动的瘦人和超重或肥胖受试者的血糖、胰岛素和胰岛素抵抗水平更高[校正后]。然而，身体活动水平被归类为HEPA的超重或肥胖志愿者的血糖和胰岛素敏感性水平相似，胰岛素水平低于不活跃的瘦人。在考虑多个社会和生物学因素的情况下，HOMA与身体活动之间的线性回归分析表明，身体活动（代谢当量×分钟×周-1）、年龄、BMI和总能量摄入是HOMA的重要预测因素，而腰围等其他因素未达到统计学意义。
我们的数据表明，身体活动是影响胰岛素敏感性的重要因素，增加身体活动可能会改善肥胖对胰岛素敏感性的众所周知的影响。
