Li Yue, Mogul David J
Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA.
J Clin Neurophysiol. 2007 Apr;24(2):197-204. doi: 10.1097/WNP.0b013e31803991c3.
Epilepsy is among the most common neurologic disorders, yet it is estimated that about one third of patients do not respond favorably to currently available drug treatments and up to 50% experience major side effects of these treatments. Although surgical resection of seizure foci can provide reduction or cessation of seizure incidents, a significant fraction of pharmacologically intractable seizure patients are not considered viable candidates for such procedures. Research advances in applying electrical stimulation as an alternative treatment for intractable epilepsy have been reported. The primary focus of these studies has been the search for optimized stimulation protocols by which to electrically suppress, revert or prevent seizures. In this review, the authors discuss some of the promising results that have been achieved. These results are organized in three broad categories based on how such protocols are generated. They focus on how information of the electrical activity in the brain is incorporated in the control schemes, namely: open loop, semiclosed loop, and closed loop protocols. Benefits, potential promises, and challenges of these different control techniques are discussed.
癫痫是最常见的神经系统疾病之一，但据估计，约有三分之一的患者对目前可用的药物治疗反应不佳，高达50%的患者会经历这些治疗的主要副作用。虽然手术切除癫痫病灶可以减少或停止癫痫发作，但相当一部分药物难治性癫痫患者不被认为是这种手术的合适候选人。已有报道称在应用电刺激作为难治性癫痫的替代治疗方面取得了研究进展。这些研究的主要重点是寻找优化的刺激方案，通过该方案来电抑制、逆转或预防癫痫发作。在这篇综述中，作者讨论了已经取得的一些有前景的结果。这些结果根据此类方案的生成方式分为三大类。他们关注大脑电活动信息如何纳入控制方案，即：开环、半闭环和闭环方案。讨论了这些不同控制技术的益处、潜在前景和挑战。
