San-Juan Daniel, Sarmiento Carlos Ignacio, Hernandez-Ruiz Axel, Elizondo-Zepeda Ernesto, Santos-Vázquez Gabriel, Reyes-Acevedo Gerardo, Zúñiga-Gazcón Héctor, Zamora-Jarquín Carol Marina
Department of Clinical Research, National Institute of Neurology and Neurosurgery , Mexico City , Mexico.
Department of Clinical Research, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Basic Sciences and Engineering, Autonomous Metropolitan University Campus Iztapalapa, Mexico City, Mexico.
Front Neurol. 2016 Nov 28;7:213. doi: 10.3389/fneur.2016.00213. eCollection 2016.
Transcranial alternating current stimulation (tACS) is a re-emergent neuromodulation technique that consists in the external application of oscillating electrical currents that induces changes in cortical excitability. We present the case of a 16-year-old female with pharmaco-resistant juvenile myoclonic epilepsy to 3 antiepileptic's drugs characterized by 4 myoclonic and 20 absence seizures monthly. She received tACS at 1 mA at 3 Hz pulse train during 60 min over Fp1-Fp2 (10-20 EEG international system position) during 4 consecutive days using an Endeavor™ IOM Systems device (Natus Medical Incorporated, Middleton, WI, USA). At the 1-month follow-up, she reported a 75% increase in seizures frequency (only myoclonic and tonic-clonic events) and developed a 24-h myoclonic status epilepticus that resolved with oral clonazepam and intravenous valproate. At the 2-month follow-up, the patient reported a 15-day seizure-free period.
经颅交流电刺激（tACS）是一种重新兴起的神经调节技术，它通过在外部施加振荡电流来诱导皮质兴奋性的变化。我们报告了一名16岁女性的病例，她对三种抗癫痫药物耐药，患有青少年肌阵挛性癫痫，每月有4次肌阵挛发作和20次失神发作。使用Endeavor™ IOM Systems设备（美国威斯康星州米德尔顿的Natus Medical Incorporated公司），在连续4天的时间里，每天60分钟，以1毫安、3赫兹的脉冲序列在Fp1-Fp2（国际10-20脑电图系统定位）处对她进行经颅交流电刺激。在1个月的随访中，她报告癫痫发作频率增加了75%（仅肌阵挛和强直-阵挛发作），并出现了持续24小时的肌阵挛性癫痫持续状态，通过口服氯硝西泮和静脉注射丙戊酸盐得以缓解。在2个月的随访中，患者报告有15天无癫痫发作期。
