McHale Michael T, Souther Jessica, Elkas John C, Monk Bradley J, Harrison Terry A
1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Naval Medical Center San Diego, San Diego, CA 92134, USA.
J Low Genit Tract Dis. 2007 Apr;11(2):86-9. doi: 10.1097/01.lgt.0000245039.45094.9a.
To determine the cumulative risk of cervical intraepithelial neoplasia (CIN) 2 or 3 in patients with atypical squamous cells, cannot exclude HSIL (ASC-H).
A retrospective analysis was performed to identify patients referred to the dysplasia clinic with ASC-H. Initial evaluation included colposcopy, endocervical curettage, and an ectocervical biopsy, when indicated, in all the patients. A follow-up evaluation was performed at 6 and 12 months. Cumulative histological diagnosis of CIN 2 or 3 at 12 months served as the clinical end point.
Two hundred twenty-nine patients with ASC-H and with a mean age of 32.8 years were evaluated. At the time of initial colposcopy, only 10.0% (23/229; 95% CI = 6.5%-15%) of the patients had histological evidence of CIN 2 or 3. The cumulative risk of CIN 2 or 3 was 12.2% (95% CI = 8%-17%).
Evaluation of patients with ASC-H with colposcopy does lead to the detection of CIN 2 or 3 but perhaps at a rate lower than previously reported.
确定非典型鳞状细胞不能排除高级别鳞状上皮内病变（ASC-H）患者发生宫颈上皮内瘤变（CIN）2或3级的累积风险。
进行一项回顾性分析，以确定转诊至发育异常门诊的ASC-H患者。所有患者的初始评估包括阴道镜检查、宫颈管刮除术，必要时进行宫颈活检。在6个月和12个月时进行随访评估。以12个月时CIN 2或3级的累积组织学诊断作为临床终点。
对229例平均年龄为32.8岁的ASC-H患者进行了评估。在初次阴道镜检查时，只有10.0%（23/229；95%CI = 6.5%-15%）的患者有CIN 2或3级的组织学证据。CIN 2或3级的累积风险为12.2%（95%CI = 8%-17%）。
通过阴道镜检查对ASC-H患者进行评估确实能检测出CIN 2或3级，但检出率可能低于先前报道。
