基于海藻硫酸化多糖的抗凝血剂的药效学参数
Pharmacodynamic parameters of anticoagulants based on sulfated polysaccharides from marine algae.
作者信息
Drozd N N, Tolstenkov A S, Makarov V A, Kuznetsova T A, Besednova N N, Shevchenko N M, Zvyagintseva T N
机构信息
Department of Pathology and Pharmacology of Hemostasis , Hematology Research Center, Russian Academy of Medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2006 Nov;142(5):591-3. doi: 10.1007/s10517-006-0426-3.
Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed quantitative differences in the action of fucoidans can result from different sulfation degree and the presence of various types of glycoside bonds in polysaccharide molecules.
从短巨藻和菊苣海带中分离出的岩藻聚糖可抑制凝血系统中的凝血酶和Xa因子。在大鼠中，静脉注射岩藻聚糖可使血浆抗凝活性呈剂量依赖性增加。岩藻聚糖可与硫酸鱼精蛋白形成复合物。观察到的岩藻聚糖作用的定量差异可能源于多糖分子中不同的硫酸化程度和各种糖苷键的存在。
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