哮喘患者免疫指标和血清褪黑素的昼夜变化
Circadian variations in immune values and serum melatonin in asthmatics.
作者信息
Litvinenko G I, Shurlygina A V, Shirinskii V S, Nepomnyashchikh V M, Shirinskii I V, Leonova M I, Krugleeva O L, Grigoryeva A E, Kozlov V A, Trufakin V A
机构信息
Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of medical Sciences, Novosibirsk.
出版信息
Bull Exp Biol Med. 2006 Nov;142(5):605-8. doi: 10.1007/s10517-006-0430-7.
Circadian variations in the immune status and serum melatonin were studied in asthmatics during exacerbation stage before and after treatment. Deviations from the normal (donor) immunogram values at 9.00 and 21.00 and decreased correlations between immune values and blood melatonin level were detected. The correlations of immune values between each other and with melatonin over the circadian cycle increased after treatment.
在哮喘患者病情加重期治疗前后，研究了其免疫状态和血清褪黑素的昼夜变化。检测到9点和21点时免疫图谱值偏离正常（供体）值，且免疫值与血褪黑素水平之间的相关性降低。治疗后，昼夜周期内免疫值之间以及与褪黑素之间的相关性增加。
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