Kim Jung-whan, Gao Ping, Dang Chi V
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Cancer Metastasis Rev. 2007 Jun;26(2):291-8. doi: 10.1007/s10555-007-9060-4.
Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells. In this review, the roles of hypoxia, the hypoxia inducible factors, oncogenes and tumor suppressors in metabolic adaptation of tumors are discussed. These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers.
快速生长的肿瘤总是包含缺氧区域。通过血管生成、增强葡萄糖代谢以及减少但优化线粒体呼吸对缺氧的适应性反应赋予了缺氧肿瘤细胞生存和生长优势。在本综述中，讨论了缺氧、缺氧诱导因子、癌基因和肿瘤抑制因子在肿瘤代谢适应中的作用。这些对肿瘤缺氧代谢改变的新见解有望引导我们针对肿瘤生物能量学来治疗癌症。
