Gouel Pierrick, Decazes Pierre, Vera Pierre, Gardin Isabelle, Thureau Sébastien, Bohn Pierre
Département d'Imagerie, Centre Henri Becquerel, Rouen, France.
QuantIF-LITIS, EA 4108, IRIB, Université de Rouen, Rouen, France.
Front Med (Lausanne). 2023 Feb 9;10:1055062. doi: 10.3389/fmed.2023.1055062. eCollection 2023.
Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular imaging allows to approach these variations, but the tracers used have their own limitations. PET imaging has the disadvantage of low resolution and must take into account molecular biodistribution, but has the advantage of high targeting accuracy. The relationship between the signal in MRI imaging and oxygen is complex but hopefully it would lead to the detection of truly oxygen-depleted tissue. Different ways of imaging hypoxia are discussed in this review, with nuclear medicine tracers such as [F]-FMISO, [F]-FAZA, or [Cu]-ATSM but also with MRI techniques such as perfusion imaging, diffusion MRI or oxygen-enhanced MRI. Hypoxia is a pejorative factor regarding aggressiveness, tumor dissemination and resistance to treatments. Therefore, having accurate tools is particularly important.
肿瘤缺氧在时间和空间上都是一种复杂且不断演变的现象。分子成像能够探究这些变化，但所使用的示踪剂有其自身局限性。正电子发射断层显像（PET）成像的缺点是分辨率低且必须考虑分子生物分布，但具有高靶向准确性的优点。磁共振成像（MRI）中的信号与氧气之间的关系很复杂，但有望实现对真正缺氧组织的检测。本综述讨论了不同的缺氧成像方法，包括使用核医学示踪剂如[F]-氟代米索（[F]-FMISO）、[F]-氟阿扎（[F]-FAZA）或[Cu]-乙硫半胱氨酸（[Cu]-ATSM），也包括使用MRI技术如灌注成像、扩散加权磁共振成像（DWI）或氧增强磁共振成像。缺氧是与肿瘤侵袭性、播散及治疗抵抗相关的不良因素。因此，拥有精确的工具尤为重要。
