Pan Ying-zi, Ren Ze-qin, Li Mei, Qiao Rong-hua
Department of Ophthalmology, the First Hospital of Peking University , Beijing 100034, China.
Zhonghua Yan Ke Za Zhi. 2006 Dec;42(12):1078-83.
To evaluate the variety of peripapillary atrophy (PPA) and its relationship with visual field among primary open angle glaucoma (POAG), normal tension glaucoma (NTG), and normal subjects with glaucoma-like disk (GLD) that had no evidence of visual field defect and retinal nerve fiber layer defect.
The study included 42 eyes of 42 patients with POAG, 40 eyes of 40 patients with NTG, and 45 eyes of normal subjects with GLD. Stereo color optic disc photographs were morphometrically evaluated by a video camera and computer system. The refractive range ( spherical equivalent) of all these subjects was between + 3.00D and -3.00D.
The alpha-zone and beta-zone of PPA occurred significantly (P <0. 05) more frequent in both patients with POAG( 100. 0% ,48. 9% )and with NTG(95.0% ,37. 5% )than that of normal subjects with GLD(85.4% ,19. 1% ) , but no difference was found between the POAG and NTG groups (P > 0. 05). The beta-zone area of PPA was significantly ( P < 0. 05) enlarged in POAG compared with GLD normal subjects. While there is no significant difference in alpha-and beta-zone area between all other groups. In glaucoma patients, The alpha-zone or the beta-zone area of PPA weakly correlated with the glaucomatous visual field defect While cup/disk area ratio showed a relatively strong correlation. Cup/disc area ratio and age were the only two risk factors for the occurrence of glaucomatous visual field defect among all the factors including PPA by logistic regression analysis.
Our results demonstrate that cup/disc area ratio is well correlated with glaucomatous visual field defect. The occurrence of alpha-zone, beta-zone, and beta-zone areas of PPA may not be a clinically useful parameter, for diagnosing or differentiating POAG and NTG .
评估原发性开角型青光眼（POAG）、正常眼压性青光眼（NTG）以及无视野缺损和视网膜神经纤维层缺损的青光眼样视盘（GLD）正常受试者的视盘周围萎缩（PPA）变化及其与视野的关系。
该研究纳入了42例POAG患者的42只眼、40例NTG患者的40只眼以及GLD正常受试者的45只眼。通过摄像机和计算机系统对视盘立体彩色照片进行形态学评估。所有这些受试者的屈光范围（等效球镜）在+3.ooD至-3.00D之间。
POAG患者（100.0%，48.9%）和NTG患者（95.0%，37.5%）的PPAα区和β区出现频率显著高于GLD正常受试者（85.4%，19.1%）（P<0.05），但POAG组和NTG组之间无差异（P>0.0s）。与GLD正常受试者相比，POAG患者的PPAβ区面积显著增大（P<0.05）。而其他所有组之间的α区和β区面积无显著差异。在青光眼患者中，PPA的α区或β区面积与青光眼性视野缺损呈弱相关，而杯盘面积比显示出相对较强的相关性。通过逻辑回归分析，在包括PPA在内的所有因素中，杯盘面积比和年龄是青光眼性视野缺损发生的仅有的两个危险因素。
我们的结果表明，杯盘面积比与青光眼性视野缺损密切相关。PPA的α区、β区及β区面积的出现可能不是诊断或鉴别POAG和NTG的临床有用参数。
