Oertel R, Kirch W, Klemm E
Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Germany.
Pharmazie. 2007 Mar;62(3):239-40.
After iv administration of 200 mg prednisolone in patients with perilymph fistula, concentrations of the drug in the cochlea were determined. A specially adapted LC method was used for analysis. Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15-25 min, and 338 ng/ml after 30-45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively.
在给外淋巴瘘患者静脉注射200毫克泼尼松龙后，测定了该药物在耳蜗中的浓度。采用了一种经过特殊改良的液相色谱法进行分析。外淋巴液中泼尼松龙的平均浓度在15 - 25分钟后达到95纳克/毫升，在30 - 45分钟后达到338纳克/毫升。这些值分别达到相应血清浓度的8%和41%。
