Niedermeyer Hans P, Zahneisen Georg, Luppa Peter, Busch Raymonde, Arnold Wolfgang
Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Audiol Neurootol. 2003 Nov-Dec;8(6):316-21. doi: 10.1159/000073516.
Cortisone is used in various inner ear disorders such as sudden hearing loss. However, it is not known if the doses of prednisolone employed in therapy increase the cortisol level in the inner ear. To evaluate the level of cortisol within the perilymph after intravenous administration of 125 and 250 mg of prednisolone, serum and perilymph samples of 29 consecutive patients with clinical otosclerosis subjected to stapedectomy were collected. Cortisol levels were determined by RIA. The perilymphatic cortisol level was significantly increased in the group with 250 mg of prednisolone while the perilymphatic cortisol levels were not significantly different between the control group and the patients treated with 125 mg. Although the therapeutic dose of prednisolone is not known, we conclude that the application of 250 mg has a greater impact on the inner ear than 125 mg.
可的松用于各种内耳疾病，如突发性听力损失。然而，尚不清楚治疗中使用的泼尼松龙剂量是否会提高内耳中的皮质醇水平。为了评估静脉注射125毫克和250毫克泼尼松龙后外淋巴中的皮质醇水平，收集了29例接受镫骨切除术的临床耳硬化症连续患者的血清和外淋巴样本。通过放射免疫分析法测定皮质醇水平。250毫克泼尼松龙组的外淋巴皮质醇水平显著升高，而对照组和接受125毫克治疗的患者之间的外淋巴皮质醇水平无显著差异。虽然泼尼松龙的治疗剂量尚不清楚，但我们得出结论，250毫克的应用对内耳的影响比125毫克更大。
