Alaez Carmen, Gazit Ephraim, Ibarrola Blanca, Yaron Michael, Livneh Avi, Avishai Ophelia, Gorodezky Clara
Department of Immunology and Immunogenetics, Instituto de Diagnóstico y Referencia Epidemiológicos, InDRE, SSA, Mexico.
Arch Med Res. 2007 May;38(4):452-5. doi: 10.1016/j.arcmed.2006.12.001. Epub 2007 Mar 6.
The aim of this study was to investigate the contribution of the B27 subtypes to ankylosing spondylitis (AS) expression in a group of Jewish patients from Israel and to compare their distribution with that found in Mexican Mestizo patients. Several HLA-B27 alleles have been clearly associated with AS. Among them, B( *)2705 and B( *)2702 are involved in susceptibility in different populations worldwide. The aim of this study was to investigate the associated subtypes in Israel and to compare the results with Mexican Mestizos, who have Semitic genes as part of their ancestry.
This is a case/control study that included a group of 24 HLA-B27+ Israeli patients with AS and 51 B27+ healthy subjects, most of them Ashkenazi Jews. The B27 subtypes were characterized using a PCR-SSP method.
Only B( *)2702 and B( *)2705 alleles were present in AS patients. However, their allele frequency was not significantly different from that found in the control group, probably because of the small sample size: B( *)2702 (patients 62.5% vs. controls 41.2%, OR = 2.31) and B( *)2705 (patients 37.5% vs. controls 50.9%). Two additional alleles were present only in the controls in low frequency: B( *)2707(5.9%) and B( *)2701(1.9%). It is clear that the major susceptibility allele in Ashkenazi Jews from Israel is B( *)2702.
The only allele conferring risk to AS expression in Israeli Jews was B( *)2702, as was previously described in Mexican Mestizos. Populations of Mediterranean ancestry, such as Latin Americans, should be further explored to understand the contribution of ethnicity to the etiopathogenesis of AS.
本研究旨在调查B27亚型对一组来自以色列的犹太患者强直性脊柱炎（AS）表达的贡献，并将其分布与墨西哥梅斯蒂索患者的分布进行比较。几种HLA - B27等位基因已明确与AS相关。其中，B（）2705和B（）2702在全球不同人群的易感性中起作用。本研究的目的是调查以色列的相关亚型，并将结果与具有闪米特基因作为其祖先一部分的墨西哥梅斯蒂索人进行比较。
这是一项病例对照研究，包括一组24名HLA - B27阳性的以色列AS患者和51名B27阳性的健康受试者，其中大多数是阿什肯纳兹犹太人。使用PCR - SSP方法对B27亚型进行鉴定。
AS患者中仅存在B（）2702和B（）2705等位基因。然而，它们的等位基因频率与对照组相比无显著差异，可能是由于样本量小：B（）2702（患者62.5%对对照组41.2%，OR = 2.31）和B（）2705（患者37.5%对对照组50.9%）。另外两个等位基因仅在对照组中低频出现：B（）2707（5.9%）和B（）2701（1.9%）。显然，来自以色列的阿什肯纳兹犹太人中的主要易感等位基因是B（*）2702。
如先前在墨西哥梅斯蒂索人中所描述的那样，在以色列犹太人中唯一赋予AS表达风险的等位基因是B（*）2702。应进一步探索地中海血统的人群，如拉丁美洲人，以了解种族对AS发病机制的贡献。
