[克罗地亚人群中HLA - B27基因亚型的变异与强直性脊柱炎易感性]

[Variation in HLA-B27 gene subtypes and susceptibility of ankylosing spondylitis in the Croatian population].

作者信息

Grubić Z, Kerhin-Brkljacić V, Perić P, Cecuk E, Kastelan A

机构信息

Zavod za tipizaciju tkiva, KBC Zogreb, Kispatićeva 12, 10000 Zagreb.

出版信息

Reumatizam. 2001;48(1):7-11.

PMID:12476735

Abstract

The differences in amino acid residues of HLA-B27 subtypes are minor, but may play role in pathogenesis of ankylosing spondylitis (AS). Aim of this study was to investigate of frequency of B27 subtypes in Croatian AS patients and B27 positive healthy controls. Group of 50 AS patients and 38 B27 positive controls were typed for B27 subtypes by PCR-SSP method. In the group of AS patients we found four subtypes: B2705 (83.0%), B2702 (13.2%), while remaining two alleles B2701 and B2704 had one individual each. In the group of B27+ controls we also observed B2705 (76.3%) as most frequent allele while frequency of B2702 was 21.1%. No significant evidence for association between AS and a particular HLA-B27 subtype in the Croatian population were found.

摘要

HLA - B27各亚型的氨基酸残基差异较小，但可能在强直性脊柱炎（AS）的发病机制中起作用。本研究的目的是调查克罗地亚AS患者和B27阳性健康对照中B27亚型的频率。采用PCR - SSP方法对50例AS患者和38例B27阳性对照进行B27亚型分型。在AS患者组中，我们发现了四种亚型：B2705（83.0%）、B2702（13.2%），而其余两个等位基因B2701和B2704各有1例。在B27 + 对照中，我们也观察到B2705（76.3%）是最常见的等位基因，而B2702的频率为21.1%。在克罗地亚人群中，未发现AS与特定HLA - B27亚型之间存在显著关联的证据。