Rybakowski Janusz K, Borkowska Alina, Skibinska Maria, Hauser Joanna
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland.
Psychiatr Genet. 2007 Jun;17(3):201-4. doi: 10.1097/YPG.0b013e3280991219.
The glutamatergic system has been implicated in the pathogenesis and prefrontal cortex dysfunctions in schizophrenia. The Src-family tyrosine kinase Fyn plays a key role in the interaction between brain-derived neurotrophic factor and glutamatergic receptor N-methyl-D-aspartate, in prefrontal cortex. We estimated an association between three polymorphisms of Fyn gene and performance on the Wisconsin Card Sorting Test, measuring prefrontal cortex functions, in 188 schizophrenic patients. Patients with T/T genotype of IVS10+T/C polymorphism and T/T genotype of Ex12+894T/G polymorphism made significantly less perseverative errors in the Wisconsin Card Sorting Test compared with patients with remaining genotypes, and obtained numerically better results in other Wisconsin Card Sorting Test domains. No significant differences in Wisconsin Card Sorting Test performance were found as to -93 A/G polymorphism. The main finding of the study is showing a relationship between polymorphisms of the Fyn gene, related to the function of glutamatergic system, and a performance on neuropsychological test of prefrontal cortex activity in schizophrenic patients.
谷氨酸能系统与精神分裂症的发病机制及前额叶皮质功能障碍有关。Src家族酪氨酸激酶Fyn在前额叶皮质中，在脑源性神经营养因子与谷氨酸能受体N-甲基-D-天冬氨酸的相互作用中起关键作用。我们评估了188例精神分裂症患者中Fyn基因的三种多态性与威斯康星卡片分类测验表现之间的关联，该测验用于测量前额叶皮质功能。与具有其他基因型的患者相比，IVS10 + T/C多态性的T/T基因型和Ex12 + 894T/G多态性的T/T基因型患者在威斯康星卡片分类测验中出现的持续性错误明显更少，并且在威斯康星卡片分类测验的其他方面获得了数值上更好的结果。关于-93 A/G多态性，在威斯康星卡片分类测验表现上未发现显著差异。该研究的主要发现表明，与谷氨酸能系统功能相关的Fyn基因多态性与精神分裂症患者前额叶皮质活动的神经心理测验表现之间存在关联。
