Puloski Shannon K T, Griffin Anthony, Ferguson Peter C, Bell R S, Wunder Jay S
The University Musculoskeletal Oncology Unit, Mt Sinai Hospital, Toronto, Ontario, Canada.
Clin Orthop Relat Res. 2007 Jun;459:154-60. doi: 10.1097/BLO.0b013e318059b91f.
We aimed to determine whether wide excision and radiocarpal arthrodesis in patients with aggressive tumors of the distal radius resulted in more significant functional deficit than joint salvage procedures. We compared functional outcomes, surgical complications, and local tumor relapse in 33 consecutive patients. Fourteen patients initially had joint-sparing procedures, whereas 19 underwent wide resection and arthrodesis. At minimum final followup of 18 months (mean, 96 months; range, 18-204 months), local tumor relapse occurred in five of 14 patients after joint salvage versus zero of 19 after arthrodesis. Two of five patients with tumor recurrence retained their native joints, whereas three underwent resection and arthrodesis. Six of 19 patients had complications, including one nonunion, for which we performed additional surgery after arthrodesis. All patients remained disease-free at followup and none developed metastases. Disabilities of the Arm, Shoulder and Hand score, Toronto Extremity Salvage Score, and Musculoskeletal Tumor Society scores all indicated more disability after arthrodesis. Persistent pain, radiographic wrist arthritis, and weaker grip strength was seen in some patients following joint salvage. Whenever possible, joint preservation is preferable for the result of better extremity function, but weaker grip, higher local tumor relapse, and late arthritis remain concerns.
我们旨在确定,对于桡骨远端侵袭性肿瘤患者,广泛切除与桡腕关节融合术相比,是否比关节挽救手术导致更显著的功能缺陷。我们比较了33例连续患者的功能结果、手术并发症和局部肿瘤复发情况。14例患者最初接受了保关节手术,而19例接受了广泛切除和关节融合术。在至少18个月的最终随访(平均96个月;范围18 - 204个月)时,保关节手术后14例患者中有5例出现局部肿瘤复发,而关节融合术后19例患者中无复发。5例肿瘤复发患者中有2例保留了其原有关节,而3例接受了切除和关节融合术。19例患者中有6例出现并发症,包括1例骨不连,为此我们在关节融合术后进行了额外手术。所有患者在随访时均无疾病复发,且均未发生转移。上肢、肩部和手部功能障碍评分、多伦多肢体挽救评分以及肌肉骨骼肿瘤学会评分均表明关节融合术后残疾程度更高。保关节手术后,部分患者出现持续疼痛、影像学显示的腕关节关节炎以及握力减弱。只要有可能,为了获得更好的肢体功能结果,保留关节更为可取,但握力较弱、局部肿瘤复发率较高以及晚期关节炎仍是需要关注的问题。