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[使用1个结核菌素单位和2个结核菌素单位进行生物病例检查结果的比较研究]

[Comparative study of biological case findings made with 1 and with 2 units of PPD].

作者信息

Dobre V

出版信息

Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1975 Oct-Dec;24(4):203-8.

PMID:174175
Abstract

Testings were carried out with one unit of PPD in 2865 children aged between 1 and 6 years in the course of 1972 and with two units of PPD in 2822 children aged between 1 and 6 years in the course of 1973. The aspect of the histograms of the two groups was clearly different, the one corresponding to 2 units, tested children showing a more marked bi-modal aspect due to the higher number of reactions of 10-11 mm in diameter (7,5%). The data resulting from the processing of the histograms, of the infecting density of the environment and of the median diameters of the reactions were not conclusive. Between the children tested with one unit 6 cases were detected (5 of which with active tuberculosis), while between those tested with 2 units 22 cases were found (one of wich with an active form of tuberculosis). Among the children tested with one unit of PPD contamination sources could be detected in 100% of the cases and in those tested with 2 units in 51,2% of the cases. The methodology based on the exclusive examination of hyperallergics to one unit of PPD and of their contacts, as compared with the examination of all positive reactions to 2 units and of their contacts has a resolution ability which is higher for an amount of work roughly 30 times less, but in the detection campaign it may omit sick children and contaminators that have not been known until the investigation. The author suggests for the examination of all positive cases with reactions to 2 units of PPD and of their contacts.

摘要

1972年,对2865名1至6岁儿童进行了1个结核菌素单位(PPD)的检测;1973年,对2822名1至6岁儿童进行了2个结核菌素单位的检测。两组的直方图情况明显不同,对应2个单位检测儿童的那一组显示出更明显的双峰形态,这是因为直径为10 - 11毫米的反应数量较多(7.5%)。对直方图、环境感染密度和反应中位直径进行处理后得到的数据并无定论。在接受1个单位检测的儿童中发现了6例(其中5例患有活动性结核病),而在接受2个单位检测的儿童中发现了22例(其中1例患有活动性结核病)。在接受1个单位PPD检测的儿童中,100%能检测到污染源,而在接受2个单位检测的儿童中,51.2%能检测到污染源。与对所有2个单位阳性反应者及其接触者进行检查相比,仅对1个单位PPD超敏者及其接触者进行检查的方法,在工作量大致减少30倍的情况下,具有更高的分辨能力,但在检测活动中可能会遗漏在调查前未知的患病儿童和传染源。作者建议对所有对2个单位PPD有反应的阳性病例及其接触者进行检查。

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