Bricheux Geneviève, Coffe Gérard, Brugerolle Guy
Biologie des Protistes, UMR CNRS6023, Université Blaise Pascal, Les Cézeaux, 63177 Aubière, France.
Mol Biochem Parasitol. 2007 Jun;153(2):133-40. doi: 10.1016/j.molbiopara.2007.02.011. Epub 2007 Mar 3.
The human parasite Trichomonas vaginalis has specific structural bodies, atractophores, associated at one end to the kinetosomes and at the other to the spindle during division. A monoclonal antibody specific for a component of this structure was obtained. It recognizes a protein with a predicted molecular mass of 477 kDa. Sequence analysis of this protein shows that P477 belongs to the family of large coiled-coil proteins, sharing a highly versatile protein folding motif adaptable to many biological functions. P477-might act as an anchor to localize cellular activities and components to the golgi centrosomal region. It may represent a new class of structural proteins, since similar proteins were found in many protozoans.
人类寄生虫阴道毛滴虫具有特定的结构体——吸引体，在分裂过程中，吸引体一端与动基体相连，另一端与纺锤体相连。获得了一种针对该结构成分的单克隆抗体。它识别一种预测分子量为477 kDa的蛋白质。对该蛋白质的序列分析表明，P477属于大型卷曲螺旋蛋白家族，具有高度通用的蛋白质折叠基序，可适应多种生物学功能。P477可能作为一种锚定物，将细胞活动和成分定位到高尔基体中心体区域。它可能代表了一类新的结构蛋白，因为在许多原生动物中都发现了类似的蛋白质。
