Mackay Trudy F C, Anholt Robert R H
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA.
Trends Genet. 2007 Jul;23(7):311-4. doi: 10.1016/j.tig.2007.03.013. Epub 2007 Apr 5.
Although the multiple interacting genes affecting complex traits can readily be dissected, how much genotype-environment interactions contribute to variation in complex traits remains elusive. A recent study that quantified several behavioral phenotypes on the same mouse strains in different laboratories decades apart, shows that some behavioral differences between laboratories remain greatly replicable, whereas others are less robust over time. This report, together with studies from Drosophila, stresses the importance of understanding genotype-environment interactions.
尽管影响复杂性状的多个相互作用基因能够轻易被剖析，但基因-环境相互作用对复杂性状变异的贡献程度仍不清楚。最近一项研究对相隔数十年的不同实验室中的同一小鼠品系的几种行为表型进行了量化，结果表明，不同实验室之间的一些行为差异仍然具有高度可重复性，而其他一些差异随着时间推移则不太稳定。这份报告以及来自果蝇的研究强调了理解基因-环境相互作用的重要性。
