血清素对应激的反应：精神分裂症中对抗异常多巴胺能反应性的保护因素？
Serotonergic response to stress: a protective factor against abnormal dopaminergic reactivity in schizophrenia?
作者信息
Brunelin Jerome, D'amato Thierry, van Os Jim, Dalery Jean, Suaud-Chagny Marie-Françoise, Saoud Mohamed
机构信息
Université de Lyon, Lyon, F-69003, France.
出版信息
Eur Psychiatry. 2007 Sep;22(6):362-4. doi: 10.1016/j.eurpsy.2007.01.1219. Epub 2007 Apr 6.
Abstract
In a double-blind-crossover-study, 10 patients with schizophrenia, 10 of their unaffected siblings and 9 healthy controls randomly received metabolic stressor and placebo. A significant HVA plasma elevation in response to stress was found in siblings whose response was intermediate to that of patients and controls. Only siblings additionally displayed an exaggerated 5HIAA response.
摘要
在一项双盲交叉研究中，10名精神分裂症患者、10名未患病的同胞以及9名健康对照者被随机给予代谢应激源和安慰剂。在反应介于患者和对照者之间的同胞中，发现其血浆高香草酸（HVA）对应激有显著升高。只有同胞还表现出5-羟吲哚乙酸（5HIAA）反应过度。
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