分裂型人格障碍中的血浆高香草酸

Plasma homovanillic acid in schizotypal personality disorder.

作者信息

Siever L J, Amin F, Coccaro E F, Bernstein D, Kavoussi R J, Kalus O, Horvath T B, Warne P, Davidson M, Davis K L

机构信息

Department of Psychiatry, Bronx VA Medical Center, NY 10468.

出版信息

Am J Psychiatry. 1991 Sep;148(9):1246-8. doi: 10.1176/ajp.148.9.1246.

DOI:10.1176/ajp.148.9.1246

PMID:1883008

Abstract

Schizotypal patients were found to have a significantly higher mean plasma HVA concentration than normal comparison subjects. Furthermore, plasma HVA concentration positively correlated with "psychotic-like" schizotypal symptoms. These results implicate dopaminergic mechanisms modulating the psychotic-like symptoms of schizotypal personality disorder.

摘要

研究发现，分裂型人格障碍患者的血浆高香草酸（HVA）平均浓度显著高于正常对照受试者。此外，血浆HVA浓度与“类精神病性”分裂型症状呈正相关。这些结果表明多巴胺能机制调节着分裂型人格障碍的类精神病性症状。