钌酸直接催化异恶唑烷氧化为3-异恶唑烷酮的首个实例。
First example of direct RuO4-catalyzed oxidation of isoxazolidines to 3-isoxazolidones.
作者信息
Piperno Anna, Chiacchio Ugo, Iannazzo Daniela, Giofrè Salvatore V, Romeo Giovanni, Romeo Roberto
机构信息
Dipartimento Farmaco-Chimico, Università di Messina, Via SS. Annunziata, Messina 98168, Italy.
出版信息
J Org Chem. 2007 May 11;72(10):3958-60. doi: 10.1021/jo070211n. Epub 2007 Apr 10.
PMID:17419650
Abstract
RuO2/NaIO4 oxidation of 3-unsubstituted isoxazolidines, under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used on both racemic and optically active isoxazolidines.
摘要
在乙酸乙酯/水双相条件下，RuO₂/NaIO₄ 对 3-未取代异恶唑烷进行氧化反应，可高产率地得到 3-异恶唑烷酮。该方法可用于外消旋和旋光活性的异恶唑烷。
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