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萨斯喀彻温省牛群的霉变草木樨(双香豆素)中毒事件。

Moldy sweet clover (dicoumarol) poisoning in Saskatchewan cattle.

作者信息

Blakley B R

出版信息

Can Vet J. 1985 Nov;26(11):357-60.

Abstract

Information pertaining to 286 animals from 56 herds affected by moldy sweet clover poisoning in Saskatchewan during 1983 was tabulated from the toxicology laboratory records. The morbidity in the affected herds was 12.1%, with a case fatality of 65.5%. Aborted fetuses and calves less than two weeks of age were affected with sweet clover poisoning most often. Sweet clover poisoning was more common during the period from January to April, 91.6% of the morbid animals were seen at this time. The rates of poisoning in beef and dairy cattle were estimated to be 0.156 and 0.095 cases per 1000 cattle respectively. Sweet clover poisoning was observed with the use of large of small bales of sweet clover in 78.9% of the affected herds. The geographical distribution of sweet clover poisoning in Saskatchewan followed the northern regions of the dark brown soil zone and the southern regions of the black soil zone which extend from the mid northwest portion of the province to the extreme southeast region.Dicoumarol concentrations were determined on a variety of tissues including liver, plasma, serum, kidney and muscle. Significant differences in the liver dicoumarol concentrations were found between animals of different ages (P = 0.045). Livers from younger animals, in particular, the fetus, contained lower concentrations of dicoumarol.

摘要

从毒理学实验室记录中整理出了1983年萨斯喀彻温省56个牛群中286头受发霉草木樨中毒影响动物的相关信息。受影响牛群的发病率为12.1%,病死率为65.5%。流产胎儿和两周龄以下的犊牛最常受到草木樨中毒的影响。草木樨中毒在1月至4月期间更为常见,此时91.6%的患病动物被发现。肉牛和奶牛的中毒率估计分别为每1000头牛0.156例和0.095例。在78.9%的受影响牛群中,使用大包或小包草木樨时观察到了草木樨中毒。萨斯喀彻温省草木樨中毒的地理分布沿着深棕色土壤区的北部地区和黑色土壤区的南部地区,该区域从该省的中西北部延伸至最东南部。测定了包括肝脏、血浆、血清、肾脏和肌肉在内的多种组织中的双香豆素浓度。不同年龄动物的肝脏双香豆素浓度存在显著差异(P = 0.045)。特别是幼龄动物(尤其是胎儿)的肝脏中双香豆素浓度较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338d/1680139/84cc5a4e77bf/canvetj00611-0055-a.jpg

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