Surgeoner G A, Flannigan G
Can Vet J. 1986 Jan;27(1):2-5.
The potential effect of lindane and its formulations on stillbirths and abortion in pregnant sows was investigated. One of four formulations of lindane were applied at five times the registered dosage to each of ten sows within two weeks of farrowing. Each animal received 5 g of lindane. Formulations included: 1) a wettable powder diluted in water, 2) emulsifiable concentrate (EC) in xylene diluted with water, 3) an emulsifiable concentrate with heavy aromatic naptha diluted with mineral oil and 4) an emulsifiable concentrate ready-to-use mineral oil concentration. Number of stillbirths were not increased in the sows and signs of toxicity were not observed.Three barrows, for each formulation, were sprayed at three times the registered dosage (1.3 g/animal) and slaughtered 24 hours later to determine if increased absorption and residues of lindane were associated with different formulations. Residues of lindane in skin, fat, back meat, brain and liver were consistently higher in those animals sprayed with the water based formulations than with oil-based formulations.
研究了林丹及其制剂对妊娠母猪死产和流产的潜在影响。在分娩前两周内,将四种林丹制剂之一以登记剂量的五倍施用于十头母猪中的每一头。每头动物接受5克林丹。制剂包括:1)用水稀释的可湿性粉剂,2)用二甲苯稀释并用水稀释的乳油(EC),3)用重质芳烃石脑油稀释并用矿物油稀释的乳油,以及4)即用型矿物油浓缩乳油。母猪的死产数量没有增加,也未观察到毒性迹象。对于每种制剂,将三头仔猪以登记剂量的三倍(1.3克/动物)进行喷雾处理,并在24小时后屠宰,以确定林丹吸收和残留量的增加是否与不同制剂有关。与油基制剂相比,用水基制剂喷雾处理的动物皮肤、脂肪、背部肌肉、大脑和肝脏中的林丹残留量始终较高。