Yan C H, Li X W, Chen X L, Wang D Q, Zhong D C, Tan T Z, Kitano H
Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu, China.
Biomaterials. 1991 Sep;12(7):640-4. doi: 10.1016/0142-9612(91)90109-n.
Biodegradable, hydrophilic gelatin microspheres (GM) with an average diameter of 70 microns were prepared by cross-linking gelatin with glutaraldehyde for hepatic intra-arterial infusion. An anticancer agent, mitomycin C (MMC), together with a radioisotope, 131I, were bound to the GM for chemotherapy and local internal radiotherapy. The 131I-labelled MMC-GM (131I-MMC-GM) could accumulate in the specific site and embolize the hepatic arteries after the hepatic intra-arterial infusion, while it caused various effects to the liver cells. The 131I-MMC-GM remained within the hepatic arteries for at least one month. In vitro release of drugs from the GM was also quantified using a dynamic dialysis method.
