Bajpai A K, Choubey Jyoti
Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, M.P. 482001, India.
J Mater Sci Mater Med. 2006 Apr;17(4):345-58. doi: 10.1007/s10856-006-8235-9.
Gelatin nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, scanning electron microscopy (SEM) and particle size analysis. The prepared nanoparticles were loaded with chloroquine phosphate (CP), a well known antimalarial drug, and the release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium. The nanoparticles were also studied for their water sorption capacity by optical microscopic method taking advantage of the aggregation of nanoparticles. The drug release processes was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles.
采用单步W/O乳液技术制备了明胶纳米颗粒，并通过红外光谱（IR）、扫描电子显微镜（SEM）和粒度分析对其进行了表征。将制备的纳米颗粒负载著名的抗疟药物磷酸氯喹（CP），并研究了包封药物的释放动力学与各种实验因素的关系，这些因素包括药物的负载百分比、纳米载体的化学结构以及pH值、温度、离子强度和释放介质的性质。还利用纳米颗粒的聚集，通过光学显微镜法研究了纳米颗粒的吸水能力。采用菲克幂定律对药物释放过程进行动力学分析，并建立了释放药物量与纳米颗粒溶胀之间的相关性。
