Johnstone R, Griffiths I D, Calvert J E
Department of Immunology, Medical School, University of Newcastle Upon Tyne, U.K.
Autoimmunity. 1991;10(1):35-9. doi: 10.3109/08916939108997145.
In man there are four subclasses of IgG which differ from each other with respect to their biological properties. Some evidence suggests that the production of IgG3 is unusually high in rheumatoid synovia. In this study secretion of IgG subclasses by synovial lymphocytes in vitro was measured using sensitive subclass-specific ELISAs. It was found that, in both synovial membrane- and synovial fluid-derived cell cultures, the general pattern of IgG subclass secretion was IgG1 greater than 2 greater than 3 greater than or equal to 4, and that, in most cultures, IgG3 was a minor subclass accounting, on average, for only 8% of the total IgG. This was similar to the percentage of this subclass in normal human serum and in culture supernatants from the patients' peripheral blood lymphocytes.
在人类中，IgG有四个亚类，它们在生物学特性方面彼此不同。一些证据表明，类风湿性滑膜炎中IgG3的产生异常高。在本研究中，使用敏感的亚类特异性酶联免疫吸附测定法（ELISA）测量了滑膜淋巴细胞在体外分泌的IgG亚类。结果发现，在滑膜组织和滑液来源的细胞培养物中，IgG亚类分泌的总体模式为IgG1＞IgG2＞IgG3≥IgG4，并且在大多数培养物中，IgG3是次要亚类，平均仅占总IgG的8%。这与该亚类在正常人血清以及患者外周血淋巴细胞培养上清液中的百分比相似。
