Suemori I
Tohoku J Exp Med. 1975 Oct;117(2):111-8.
Metabolic effects of N6,O2-dibutyryl adenosine 3',5'-monophosphate (DBcAMP) were studied in 10 anesthetized patients who were divided at random into two groups each consisting of 5 patients. DBcAMP dissolved in 200 ml of physiological saline was administered intravenously at a rate of 10 mg/min for 20 min in one group and 20 mg/min for 20 min in the other group. DBcAMP infusion at either rate increased levels of blood glucose, immunoreactive plasma insulin, blood pyruvate and blood redox-potential while it reduced levels of glycerol, non-esterified fatty acid and inorganic phosphate. These findings suggest that 200 and 400 mg of DBcAMP stimulates glycogenolysis and glycolysis but inhibits lipolysis in man.
研究了N6,O2-二丁酰腺苷3',5'-单磷酸（DBcAMP）对10例麻醉患者的代谢影响。这些患者被随机分为两组，每组5例。一组以10mg/min的速率静脉注射溶解于200ml生理盐水中的DBcAMP，持续20分钟；另一组以20mg/min的速率静脉注射，持续20分钟。无论以哪种速率输注DBcAMP，均可使血糖、免疫反应性血浆胰岛素、血丙酮酸和血液氧化还原电位水平升高，同时使甘油、非酯化脂肪酸和无机磷酸盐水平降低。这些发现表明，200mg和400mg的DBcAMP可刺激人体糖原分解和糖酵解，但抑制脂肪分解。
