Yamamoto Akira, Takahashi Naoto, Munakata Kazuo, Hosoya Tetsuo, Shiiba Masato, Okuyama Takao, Abe Kazuya, Kaneshiro Tadashi, Tsuruta Haruko, Takama Toshi, Sato Masashi
Department of Radiology, Nippon Medical School, Musashikosugi Hospital, Kawasaki, Kanagawa, Japan.
Ann Nucl Med. 2007 Feb;21(2):115-21. doi: 10.1007/BF03033989.
A newly developed program, named cardioGRAF, enabled the evaluation of left ventricular (LV) systolic and diastolic temporal parameters for the estimation of heart failure using ECG-gated myocardial perfusion SPECT (GMPS).
The feasibility of those global (g-) and regional (r-) parameters was validated to compare with gated equilibrium radionuclide angiography (ERNA) and speckle-tracking radial strain (STS) from echocardiography.
Thirty-three patients were studied using GMPS and ERNA (n=11) or GMPS and STS (n=22). The following g- or r-parameters obtained by cardioGRAF and ERNA or STS were compared: time to end systole (TES), time from end systole to peak filling rate (TPF1), time from 0 to peak filling rate (TPF2), time to peak radial strain (TPS), time from peak strain to peak negative strain rate (TP-SR1), and time from 0 to peak negative strain rate (TP-SR2).
All g-parameters were successfully obtained by cardioGRAF and ERNA. The results demonstrated good correlations (g-TES: r = 0.79, p < 0.005; g-TPF1: r = 0.75, p < 0.02; TPF2: r = 0.83, p < 0.005). The differences were 11.9 +/- 31.8 ms in g-TES, 19.9 +/- 65.4 ms in g-TPF1, and 37.7 +/- 67.4 ms in g-TPF2. All r-parameters were successfully obtained by cardioGRAF. Eight patients and 12 segments were excluded because of the inadequate quality of routine echocardiography for STS analysis. However, r-parameters obtained by cardioGRAF were significantly correlated with those of STS (r-TES and r-TPS: r = 0.61, p = 1 x 10(-8); r-TPF1 and r-TP-SR1: r = 0.69, p = 3 x 10(-11); r-TPF2 and r-TP-SR2: r = 0.76, p = 2 x 10(-15)). The differences were 22.1 +/- 38.2 ms between r-TES and r-TPS, 7.0 +/- 123.4 ms between r-TPF1 and r-TP-SR1, and 38.1 +/- 111.5 ms between r-TPF2 and r-TP-SR2.
The feasibility of evaluating systolic and diastolic temporal parameters by a new program was validated. This program has the potential to evaluate both diastolic and systolic heterogeneous wall motions which express dyssynchrony in heart failure.
一个新开发的名为cardioGRAF的程序，能够利用心电图门控心肌灌注单光子发射计算机断层扫描（GMPS）评估左心室（LV）的收缩期和舒张期时间参数，以估计心力衰竭情况。
验证这些整体（g-）和局部（r-）参数的可行性，以便与门控平衡放射性核素血管造影（ERNA）以及超声心动图的斑点追踪径向应变（STS）进行比较。
对33例患者进行了GMPS和ERNA（n = 11）或GMPS和STS（n = 22）检查。比较了通过cardioGRAF和ERNA或STS获得的以下g-或r-参数：收缩末期时间（TES）、从收缩末期到峰值充盈率的时间（TPF1）、从0到峰值充盈率的时间（TPF2）、峰值径向应变时间（TPS）、从峰值应变到峰值负应变率的时间（TP-SR1）以及从0到峰值负应变率的时间（TP-SR2）。
cardioGRAF和ERNA成功获得了所有g-参数。结果显示出良好的相关性（g-TES：r = 0.79，p < 0.005；g-TPF1：r = 0.75，p < 0.02；TPF2：r = 0.83，p < 0.005）。g-TES的差异为11.9±31.8毫秒，g-TPF1的差异为19.9±65.4毫秒，g-TPF2的差异为37.7±67.4毫秒。cardioGRAF成功获得了所有r-参数。由于常规超声心动图用于STS分析的质量欠佳，排除了8例患者和12个节段。然而，cardioGRAF获得的r-参数与STS的r-参数显著相关（r-TES和r-TPS：r = 0.61，p = 1×10⁻⁸；r-TPF1和r-TP-SR1：r = 0.69，p = 3×10⁻¹¹；r-TPF2和r-TP-SR2：r = 0.76，p = 2×10⁻¹⁵）。r-TES和r-TPS之间的差异为22.1±38.2毫秒，r-TPF1和r-TP-SR1之间的差异为7.0±123.4毫秒，r-TPF2和r-TP-SR2之间的差异为38.1±111.5毫秒。
验证了通过新程序评估收缩期和舒张期时间参数的可行性。该程序有潜力评估舒张期和收缩期的异质性室壁运动，这些运动表现出心力衰竭中的不同步。
