Higuchi Takahiro, Taki Junichi, Nakajima Kenichi, Kinuya Seigo, Ikeda Masatoshi, Namura Masanobu, Tonami Norihisa
Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan.
Ann Nucl Med. 2004 Sep;18(6):507-11. doi: 10.1007/BF02984568.
The objective of the present investigation was to determine the feasibility of assessing left ventricular systolic ejection and diastolic filling via the automatic edge detection method employing ECG-gated blood pool single-photon emission tomography (SPET GBP) data.
Thirty-five patients, who had undergone both SPET GBP and ECG-gated equilibrium blood pool scintigraphy by the planar method (planar GBP), were enrolled in this study. Planar GBP was performed with a single-headed gamma camera. From the left anterior oblique projection, data were acquired at 24 frames/cardiac cycle with ECG-gating during the equilibrium state. SPET GBP was conducted utilizing a triple-headed gamma camera, with 60 projection views over 360 degrees by 60 sec per view, in 16 frames/cardiac cycle. In each frame, left ventricular volume was determined by automatic edge detection employing a quantitative gated SPET program. Additionally, the time-volume curve was fitted by the 4th harmonics of Fourier transform. Ejection fraction (EF, %), peak ejection rate (PER, /sec), peak filling rate (PFR, /sec) and mean filling rate during the initial one-third of diastolic time (1/3 FRm) were calculated from the fitted curve. These parameters were also calculated with planar GBP data.
Left ventricular ejection and filling parameters were calculated by SPET GBP with the automatic edge detection program for all patient data. Correlation coefficients of EF, PER, PFR and 1/3 FRm between SPET and planar GBP were 0.91 (p < 0.001), 0.82 (p < 0.001), 0.78 (p < 0.001) and 0.74 (p < 0.001), respectively.
Ejection and filling rates can be calculated using SPET GBP with the edge-detection software. These parameters displayed significant correlations with those values obtained via planar GBP. Additional studies are warranted to determine the reliability of parameters with SPET GBP.
本研究的目的是确定通过使用心电图门控血池单光子发射断层扫描（SPET GBP）数据的自动边缘检测方法评估左心室收缩期射血和舒张期充盈的可行性。
本研究纳入了35例既接受过SPET GBP检查又接受过平面法心电图门控平衡血池闪烁扫描（平面GBP）的患者。平面GBP使用单头伽马相机进行。在平衡状态下，从左前斜位投影，通过心电图门控以24帧/心动周期采集数据。SPET GBP使用三头伽马相机进行，在360度范围内有60个投影视图，每个视图60秒，共16帧/心动周期。在每一帧中，使用定量门控SPET程序通过自动边缘检测确定左心室容积。此外，时间 - 容积曲线通过傅里叶变换的第四谐波进行拟合。从拟合曲线计算射血分数（EF，%）、峰值射血率（PER，/秒）、峰值充盈率（PFR，/秒）以及舒张期最初三分之一时间内的平均充盈率（1/3 FRm）。这些参数也使用平面GBP数据进行计算。
对于所有患者数据，使用自动边缘检测程序通过SPET GBP计算左心室射血和充盈参数。SPET与平面GBP之间EF、PER、PFR和1/3 FRm的相关系数分别为0.91（p < 0.001）、0.82（p < 0.001）、0.78（p < 0.001）和0.74（p < 0.001）。
使用带有边缘检测软件的SPET GBP可以计算射血率和充盈率。这些参数与通过平面GBP获得的值显示出显著相关性。有必要进行进一步研究以确定SPET GBP参数的可靠性。
