Fedeli G, Certo M, Cannizzaro O, Forti G, Gimbo G, Abagnale R, Vecchio F M
Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
Ital J Gastroenterol. 1991 Jun;23(5):261-3.
Epithelioid hemangioendothelioma is a very rare tumour of vascular origin, the most peculiar feature of which is that it is composed of endothelial cells closely resembling epithelial cells. Confirmation of its endothelial origin is achieved by positive staining for Factor VIII-related antigen or by the demonstration of Weibel-Palade bodies by electron microscopy. We report two cases of primary epithelioid hemangioendothelioma of the liver that occurred in our center in the last ten years. The first patient is a 21 year old woman who presented with a right upper quadrant pain and an echographic finding of multiple hepatic lesions suggestive of metastases. The second patient is a 32 year old woman operated on for a cerebral glioma, in whom an abdominal CT scan, performed in view of radiotherapy, revealed multiple hepatic lesions, originally interpreted as being metastatic. In both cases, diagnosis was made based on the histologic examination of biopsies have been adopted in each case: the first patient has undergone successful liver transplantation. In the second patient an attentive surveillance appeared to be the best option, due to the presence of a previous cerebral glioma.
上皮样血管内皮瘤是一种极为罕见的血管源性肿瘤，其最独特的特征是由与上皮细胞极为相似的内皮细胞组成。通过对 VIII 因子相关抗原进行阳性染色或通过电子显微镜显示魏-帕小体来证实其内皮起源。我们报告了过去十年在我们中心发生的两例原发性肝脏上皮样血管内皮瘤病例。首例患者为一名21岁女性，表现为右上腹疼痛，超声检查发现多个肝脏病变，提示为转移瘤。第二例患者是一名32岁女性，因脑胶质瘤接受手术，鉴于放疗进行腹部CT扫描时发现多个肝脏病变，最初被解释为转移瘤。在这两例病例中，均根据活检的组织学检查做出诊断：首例患者已成功接受肝移植。在第二例患者中，由于既往有脑胶质瘤，密切监测似乎是最佳选择。
