Kawabe T, Tagawa K, Unuma T, Takanashi R, Oka T
Division of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan.
Dig Dis Sci. 1987 Dec;32(12):1422-7. doi: 10.1007/BF01296670.
Epithelioid hemangioendothelioma in a young female is reported. Her symptoms were right upper quadrant pain and low-grade fever. Laboratory examinations showed an increased number of white blood cells and an elevated erythrocyte sedimentation rate. Plasma factor VIII:C was increased. The hepatic lesions were demonstrated as low-density areas by CT scan, and multiple nodules with central depression on the surface of the liver were identified by peritoneoscopy. The biopsy specimens showed spindle-shaped tumor cells set in the fibrous and myxohyalinous tissue. The tumor cells were positive for factor VIII-related antigen and Weibel-Palade bodies. The patient received transcatheter arterial embolization therapy using Gelfoam and mitomycin C following which the plasma level of factor VIII was normalized and regression of the tumors was observed.
报告了一名年轻女性的上皮样血管内皮瘤。她的症状为右上腹疼痛和低热。实验室检查显示白细胞数量增加，红细胞沉降率升高。血浆因子VIII:C升高。CT扫描显示肝脏病变为低密度区，腹腔镜检查发现肝脏表面有多个中央凹陷的结节。活检标本显示梭形肿瘤细胞位于纤维和黏液样组织中。肿瘤细胞因子VIII相关抗原和Weibel-Palade小体呈阳性。患者接受了使用明胶海绵和丝裂霉素C的经导管动脉栓塞治疗，之后血浆因子VIII水平恢复正常，且观察到肿瘤消退。
