Huang Ruo-Pan
Emory University School of Medicine, Department of Gynecology & Obstetrics, Atlanta, GA 30322, USA.
Expert Rev Proteomics. 2007 Apr;4(2):299-308. doi: 10.1586/14789450.4.2.299.
Protein arrays have shown potential applications in cancer research. After several decades of research, it has become evident that many cytokines are central to the development of cancer and its treatment. Cytokine antibody arrays that have been designed to simultaneously detect multiple cytokines are not only available, but show a diversity of applications in the study of many diseases in addition to cancer. This review will focus on the implementation of cytokine antibody arrays in many aspects of cancer research, such as biomarker discovery, molecular mechanisms of cancer development, preclinical studies and the effects of cancer compounds.
蛋白质阵列已在癌症研究中显示出潜在应用。经过几十年的研究，很明显许多细胞因子在癌症的发展及其治疗中起着核心作用。旨在同时检测多种细胞因子的细胞因子抗体阵列不仅已经问世，而且除癌症外，在许多疾病的研究中也显示出多种应用。本综述将聚焦于细胞因子抗体阵列在癌症研究诸多方面的应用，如生物标志物发现、癌症发展的分子机制、临床前研究以及癌症化合物的作用。
