Staller Jud A, Faraone Stephen V
Division of Child & Adolescent Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Expert Rev Neurother. 2007 Apr;7(4):351-62. doi: 10.1586/14737175.7.4.351.
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable condition that affects a significant number of children and adults worldwide. During the past 30 years, the diagnosis and treatment of ADHD has relied on clinical assessment and empirical experience with stimulant medications. More recently, advances in family genetic studies, molecular genetic studies, preclinical research, radiographic imaging techniques and neuropsychological evaluation have significantly enhanced our understanding of the neurobiology of ADHD. This review highlights the current central role of dopamine in the pathophysiology and treatment of ADHD and implications for future advances in diagnosis and treatment.
注意力缺陷多动障碍（ADHD）是一种具有高度遗传性的疾病，影响着全球大量儿童和成人。在过去30年里，ADHD的诊断和治疗依赖于临床评估以及使用兴奋剂药物的经验。最近，家族遗传学研究、分子遗传学研究、临床前研究、放射成像技术和神经心理学评估的进展显著增强了我们对ADHD神经生物学的理解。这篇综述强调了多巴胺目前在ADHD病理生理学和治疗中的核心作用以及对未来诊断和治疗进展的影响。
