Reilev Mette, Børch Klaus, Pryds Ole Axel
Hvidovre Hospital, Børneafdelingen, Hvidovre.
Ugeskr Laeger. 2007 Mar 26;169(13):1227-31.
Neonatal dehydration with hypernatraemia is a serious condition with risk of cerebral damage and death. Recent studies have reported a rising incidence.
A retrospective study was conducted at Hvidovre Hospital over a 5-year period to identify term or near-term infants (>35 weeks of gestation) who were admitted with a weight-loss >10%. Infants admitted between the 3rd and the 14th day of life with a discharge diagnosis code indicating dehydration were also included.
During the period a total of 89 infants were admitted and 24 had hypernatraemia. The incidence increased from 2.1 to 4.9 (RR 2,5-p >0.0008). All infants were breastfed and only 3 had had supplementation prior to admission. The weight-loss ranged between 270 and 1100 grams (equivalent to 10.1-29.7% reduction in birth weight) while lethargy and jaundice were frequent symptoms. Cerebral complications occurred for 8 infants and 2 developed permanent brain damage.
Breastfeeding should be encouraged but supplementation may be necessary for some infants. Infants born to primiparous women, infants heavy for gestational age and infants who do not thrive on day 4-5 appear to have a high risk. These infants could be identified by regular weighing and, if necessary, supplementation and follow-up should be instituted.
新生儿高钠血症性脱水是一种严重病症,存在脑损伤和死亡风险。近期研究报告称其发病率呈上升趋势。
在维德夫勒医院进行了一项为期5年的回顾性研究,以确定足月或近足月(妊娠>35周)且体重减轻超过10%入院的婴儿。出生后第3天至第14天入院且出院诊断代码显示脱水的婴儿也被纳入研究。
在此期间,共89名婴儿入院,其中24名患有高钠血症。发病率从2.1升至4.9(相对危险度2.5,P>0.0008)。所有婴儿均为母乳喂养,入院前仅有3名婴儿接受过补充喂养。体重减轻范围在270至1100克之间(相当于出生体重降低10.1 - 29.7%),嗜睡和黄疸是常见症状。8名婴儿出现脑部并发症,2名婴儿出现永久性脑损伤。
应鼓励母乳喂养,但部分婴儿可能需要补充喂养。初产妇所生婴儿、大于胎龄儿以及出生后第4 - 5天生长不良的婴儿似乎风险较高。可通过定期称重识别这些婴儿,如有必要,应进行补充喂养并随访。