Valvassori Samira S, Frey Benício N, Martins Márcio R, Réus Gislaine Z, Schimidtz Filipe, Inácio Cecília G, Kapczinski Flávio, Quevedo João
Laboratory of Neuroscience, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense Criciúma, SC, Brazil.
Behav Pharmacol. 2007 May;18(3):205-12. doi: 10.1097/FBP.0b013e328153daf5.
An increasing debate exists about the potential of early exposure to methylphenidate to increase the risk for drug abuse. In addition, little is known about the neurobiological effects of early exposure to methylphenidate. This study was designed to investigate whether chronic treatment with methylphenidate induces behavioral sensitization to subsequent methylphenidate and D-amphetamine challenge in adolescent Wistar rats. Young Wistar rats (P25) were treated with either methylphenidate (1, 2, or 10 mg/kg, intraperitoneally) or saline for 28 days. After 14 days of washout, animals were challenged with methylphenidate 2.5 mg/kg intraperitoneally or D-amphetamine 2 mg/kg intraperitoneally (P67). Locomotor behavior was assessed using the open field test. Rats chronically treated with methylphenidate in the adolescent period showed augmented locomotor sensitization to D-amphetamine but not to methylphenidate in the adult phase. These findings suggest that early exposure do methylphenidate might increase the risk for subsequent D-amphetamine abuse. Further studies focusing on the neurobiological effects of early exposure to methylphenidate are warranted.
关于早期接触哌甲酯是否会增加药物滥用风险的潜在问题，存在着越来越多的争论。此外，对于早期接触哌甲酯的神经生物学效应知之甚少。本研究旨在调查在青春期Wistar大鼠中，哌甲酯的慢性治疗是否会诱导对随后的哌甲酯和右旋苯丙胺激发产生行为敏化。幼年Wistar大鼠（出生后25天）接受哌甲酯（1、2或10毫克/千克，腹腔注射）或生理盐水治疗28天。在洗脱14天后，动物接受2.5毫克/千克哌甲酯腹腔注射或2毫克/千克右旋苯丙胺腹腔注射激发（出生后67天）。使用旷场试验评估运动行为。青春期接受哌甲酯慢性治疗的大鼠在成年期对右旋苯丙胺表现出增强的运动敏化，但对哌甲酯没有。这些发现表明，早期接触哌甲酯可能会增加随后右旋苯丙胺滥用的风险。有必要进一步开展关于早期接触哌甲酯神经生物学效应的研究。
