慢性铍病和铍致敏中的肿瘤坏死因子-α基因多态性

TNF-alpha polymorphisms in chronic beryllium disease and beryllium sensitization.

作者信息

McCanlies Erin C, Schuler Christine R, Kreiss Kathleen, Frye Bonnie L, Ensey James S, Weston Ainsley

机构信息

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. EIM4@CDC/GOV

出版信息

J Occup Environ Med. 2007 Apr;49(4):446-52. doi: 10.1097/JOM.0b013e31803b9499.

DOI:10.1097/JOM.0b013e31803b9499

PMID:17426528

Abstract

OBJECTIVE

Tumor necrosis factor-alpha (TNF-alpha) is a potent cytokine involved in normal immune functions. The aim of this study was to investigate if there is an association between chronic beryllium disease or beryllium sensitization and two variants of the TNF-alpha gene located at -308 and -238 called TNF-alpha-30802 and TNF-alpha-23802.

METHODS

TNF-alpha-308 and TNF-alpha-238 genotyping was conducted in a large, population-based cohort consisting of 886 beryllium workers (92 individuals with chronic beryllium disease, 64 who were beryllium sensitized, and 730 individuals without sensitization or disease).

RESULTS

The odds of chronic beryllium disease in the presence of at least one TNF-alpha-30802 or TNF-alpha-23802 allele was not significant (OR=1.0; 95% CI=0.7, 1.7 and OR=0.8; 95% CI=0.4, 1.6). This was true regardless of whether a worker was homozygous or heterozygous for TNF-alpha-30802 or TNF-alpha-23802. Similarly, neither allele was associated with sensitization (P>0.05).

CONCLUSIONS

Unlike an earlier report, there was no association between these specific TNF-alpha alleles and either chronic beryllium disease or sensitization to beryllium.

摘要

目的

肿瘤坏死因子-α（TNF-α）是一种参与正常免疫功能的强效细胞因子。本研究的目的是调查慢性铍病或铍致敏与位于-308和-238的TNF-α基因的两个变体（称为TNF-α-30802和TNF-α-23802）之间是否存在关联。

方法

对一个基于人群的大型队列中的886名铍作业工人进行了TNF-α-308和TNF-α-238基因分型，其中包括92名慢性铍病患者、64名铍致敏者和730名无致敏或疾病者。

结果

存在至少一个TNF-α-30802或TNF-α-23802等位基因时患慢性铍病的几率无显著差异（比值比=1.0；95%置信区间=0.7, 1.7；比值比=0.8；95%置信区间=0.4, 1.6）。无论工人是TNF-α-30802或TNF-α-23802的纯合子还是杂合子，情况均如此。同样，这两个等位基因均与致敏无关（P>0.05）。