避水应激激活雌性大鼠的结肠肌间神经元。
Water avoidance stress activates colonic myenteric neurons in female rats.
作者信息
Miampamba Marcel, Million Mulugeta, Yuan Pu-Qing, Larauche Muriel, Taché Yvette
机构信息
Department of Medicine, Center for Neurovisceral Sciences and Women's Health and CURE: Digestive Diseases Research Center and Brain Research Institute, University of California, Los Angeles, California, USA.
出版信息
Neuroreport. 2007 May 7;18(7):679-82. doi: 10.1097/WNR.0b013e3280bef7f8.
Abstract
Stress stimulates colonic motor function and plays a role in functional bowel disorders, prevalently in women. We examined, in conscious female rats, the influence of water avoidance stress for 60 min on colonic myenteric neuron activity using immunohistochemical detection of Fos as a marker of neuronal activity. In control rats, Fos immunoreactive nuclei were rare in proximal and distal colon and no defecation was observed. Water avoidance stimulated fecal pellet output, which was associated with Fos expression in myenteric ganglia of proximal and distal colon including in a population of peripheral choline acetyltransferase-immunoreactive neurons. Atropine blocked fecal pellet output but not Fos expression in myenteric ganglia. These results indicate that psychological stress stimulates the activity of colonic cholinergic myenteric neurons.
摘要
应激会刺激结肠运动功能，并在功能性肠病中起作用，女性更为普遍。我们在清醒的雌性大鼠中，使用Fos免疫组化检测作为神经元活动的标志物，研究了60分钟的避水应激对结肠肌间神经元活动的影响。在对照大鼠中，近端和远端结肠中Fos免疫反应性细胞核很少见，且未观察到排便。避水应激刺激了粪便排出，这与近端和远端结肠肌间神经节中的Fos表达有关，包括一群外周胆碱乙酰转移酶免疫反应性神经元。阿托品阻断了粪便排出，但未阻断肌间神经节中的Fos表达。这些结果表明，心理应激会刺激结肠胆碱能肌间神经元的活动。
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