Taché Y, Martinez V, Million M, Wang L
CURE: Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, Bldg. 115, Rm. 203, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA.
Am J Physiol Gastrointest Liver Physiol. 2001 Feb;280(2):G173-7. doi: 10.1152/ajpgi.2001.280.2.G173.
Alterations of gastrointestinal (GI) motor function are part of the visceral responses to stress. Inhibition of gastric emptying and stimulation of colonic motor function are the commonly encountered patterns induced by various stressors. Activation of brain corticotropin-releasing factor (CRF) receptors mediates stress-related inhibition of upper GI and stimulation of lower GI motor function through interaction with different CRF receptor subtypes. CRF subtype 1 receptors are involved in the colonic and anxiogenic responses to stress and may have clinical relevance in the comorbidity of anxiety/depression and irritable bowel syndrome.
胃肠道（GI）运动功能的改变是应激内脏反应的一部分。胃排空抑制和结肠运动功能刺激是各种应激源诱导的常见模式。脑促肾上腺皮质激素释放因子（CRF）受体的激活通过与不同的CRF受体亚型相互作用，介导应激相关的上消化道抑制和下消化道运动功能刺激。CRF 1型受体参与应激的结肠和焦虑反应，可能在焦虑/抑郁与肠易激综合征的共病中具有临床相关性。
